Biosynthesis of α-pyrones

• Till F. Schäberle

Beilstein J. Org. Chem. 2016, 12, 571–588, doi:10.3762/bjoc.12.56

• ketosynthases which catalyze Claisen-like condensation reactions, will be presented. Keywords: α-pyrones; biological activity; interconnecting ketosynthases; natural product; polyketides; Introduction α-Pyrones (1, also 2-pyrones) represent a moiety widespread in nature (Figure 1). The motif of a six-membered

• isolation studies and lead discovery. Now, new insights into the biosynthesis of these molecules through chain interconnecting ketosynthases were obtained. This opens up the possibility to use these enzymes as tools; both, in bio- as well as in semi-synthetic approaches. The potential of these enzymes in